I have a Windows machine, and want to run Open edX devstack.
Devstack runs in a Vagrant Virtualbox machine. Both Vagrant and Virtualbox are supported on Windows, so it seems like this should work. The problem is that both NFS and symlinks are required, and those can be difficult with Windows as a guest operating system.
These instructions seem to have worked for people: http://www.appsembler.com/blog/setting-up-openedx-devstack-on-windows-8/