By default, macOS uses a case insensitive filesystem; occasionally this causes problems, for example we have encountered dependency combinations involving module names that differ only by case (ModuleNotFoundError: No module named 'Crypto'), also git behaves very badly if a repository has case-differentiated files.
Fortunately, it's fairly easy to set up a case-sensitive volume and move your development work to it.
Note: any added volumes must be encryped and backed up in CrashPlan per IT policy (also, it's just good sense)
The following assumes all edx repos and development are currently in a directory called edxdev; this is not a standard, substitute as needed for your workarea.
Add a "Dev" volume in Disk Utility of type “APFS (Case-Sensitive, Encrypted)”
Quit applications that might be using files in edxdev; Docker, VSCode, etc
Copy edxdev to the new volume
mv edxdev edxdev-old (or just rm if you're feeling lucky/foolish)
Add a link: ln -s /Volumes/Dev/edxdev .
Re-open VSCode etc., confirm that they are following the symlink (copy a file path and see that it doesn't include edxdev-old, for example)
Add "Dev" volume to CrashPlan:
Open Code42, either directly or from the menubar
Sign in with your OneLogin credentials if needed
Click "Manage Files..."
Above the file listing, click the name of your computer